Interferon Production by Double-stranded RNA: A Comparison of Induction by Reovirus to that by a Synthetic Double-stranded Polynucleotide

Interferon production by double-stranded RNA: a comparison of induction by reovirus to that by a synthetic double-stranded polynucleotide.

Induction of interferon synthesis by synthetic double-stranded polynucleotides.

It has been shown recently that double-stranded ribonucleic acid (RNA) from different sources stimulates the release of interferon into the circulatory system when injected intravenously into rabbits. The same RNA preparations protected mice from viral infections and prevented the viral cytopathic effect in cultures of rabbit kidney cells (A. K. Field et al., Proc. Natl. Acad. Sci. U.S. 58:2102...

RNA recognition by a Staufen double-stranded RNA-binding domain.

The double-stranded RNA-binding domain (dsRBD) is a common RNA-binding motif found in many proteins involved in RNA maturation and localization. To determine how this domain recognizes RNA, we have studied the third dsRBD from Drosophila Staufen. The domain binds optimally to RNA stem-loops containing 12 uninterrupted base pairs, and we have identified the amino acids required for this interact...

Interferon, double-stranded RNA, and protein phosphorylation.

We reported earlier that the addition of double-stranded RNA and ATP increases the endonuclease activity more in an extract of Ehrlich ascites tumor cells which have been treated with an interferon preparation than in a comparable extract from control cells. We report here that the addition of double-stranded RNA to an extract from Ehrlich ascites tumor cells which have been treated with an int...

Induction of antiviral immunity by double-stranded RNA in a marine invertebrate.

Vertebrates mount a strong innate immune response against viruses, largely by activating the interferon system. Double-stranded RNA (dsRNA), a common intermediate formed during the life cycle of many viruses, is a potent trigger of this response. In contrast, no general inducible antiviral defense mechanism has been reported in any invertebrate. Here we show that dsRNA induces antiviral protect...